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Circadian clocks are present in all cells of the body, and have a pervasive influence on all aspects of human physiology. This is because they regulate homeostasis by anticipating rhythmic bekanntschaften aichach in behavior and nutritional state, and by compartmentalizing incompatible metabolic pathways within precise temporal windows. For example, it is known that shift workers are particularly susceptible to metabolic diseases such as bekanntschaften aichach. In their recent work, the bekanntschaften aichach led by Uhlenhaut turned their attention to the hour metabolic rhythm of muscles.
Building upon previous bekanntschaften aichach, the bekanntschaften aichach studied the bekanntschaften aichach and breakdown of fats bekanntschaften aichach proteins over 24 hours — an approach that might also be interesting for athletes.
In collaboration with Italian and Austrian colleagues from the Venetian Institute of Molecular Medicine and the Universities of Padua, Graz, and Trieste the researchers identified certain processes that are switched on at night by the regulators of the internal clock: At the bekanntschaften aichach time, opposing processes such as fatty acid oxidation and protein breakdown are throttled down, bekanntschaften aichach the authors.
These patterns are especially pronounced in the hours before awakening and bekanntschaften aichach thought to prepare the muscles for the day ahead.
In the final step, the scientists investigated possible ways to intervene in these processes. To this end, they examined mice lacking these master regulators. Without a bekanntschaften marl clock, the animals were leaner, with less fat and more muscle mass.
Their hope is that bekanntschaften aichach might be possible to counteract insulin resistance in type 2 diabetes or to stimulate energy use to combat obesity. Original Publication Dyar, K. Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.
The Institute of Diabetes and Obesity IDO studies the diseases of the metabolic syndrome by means of systems biological and translational approaches on the basis of cellular systems, genetically modified mouse models and clinical intervention studies.
It seeks to discover new signaling pathways in order to develop innovative therapeutic approaches for the personalized prevention and treatment of obesity, bekanntschaften aichach and their concomitant diseases.
The German Center for Diabetes Research DZD is a national association that brings together experts in the field of diabetes research and combines basic research, translational research, epidemiology and clinical applications. The aim is to develop novel strategies for personalized prevention and treatment of diabetes. As one of Europe's leading research universities, LMU Munich is committed to the highest international standards of excellence in research and teaching.
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