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Semb aims to develop safe approaches for up-scaled production of insulin-producing beta cells from human pluripotent stem cells hPSCs. He and his team have recently made major breakthroughs towards this goal. The scientists were able to establish a technology which allows the precursors of beta cells to be selectively isolated from a heterogeneous pool of differentiated hPSCs. As a next step, Semb and his team found new ways to specifically promote the proliferation of these beta cell precursors. Semb's long-term objective is to develop a safe and scalable stem cell therapy for people with type 1 diabetes.

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